Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is cancer with a high prevalence in the world, Asia, and Indonesia. Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and signi...

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Main Authors: Susanto, Hendra, Yunisa, Dinda Tri, Taufiq, Ahmad, Putra, Wira Eka, Jannah, Nur Raiyan, Putri, Shabrina Andira, Dewi, Ikke Astrid, Febriyanti, Qori Dini Ayu, Mufidah, Ikfi Nihayatul
Format: Conference Proceeding
Language:English
Subjects:
Cancer
Fibrosis
Growth factors
Liver
Liver cancer
Metabolic disorders
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Summary:Hepatocellular carcinoma (HCC) is cancer with a high prevalence in the world, Asia, and Indonesia. Some HCC can be caused by a viral infection, consuming alcohol for an extended period, and has recently been associated with metabolic syndrome. Liver fibrogenesis is the initial stage of HCC and significantly correlates to the transforming growth factor-beta (TGF-β) expression. TGF-β leads to disease progression stages, from early liver damage through inflammation and fibrosis to cirrhosis and (HCC). The purpose of this study is to investigate the effect of green material Moringa oleifera on the expression of TGF-β in the mice model develop to HCC. This study was conducted using a BALB C mice model treated with intraperitoneal injections of green material Moringa oleifera +CCl4 at a dose of 1 µL/1 g of BW for six weeks. The result shows a significant effect of green material Moringa oleifera on the decrease in TGF-β expression. Hence, green material Moringa oleifera can be a potential preventative agent for liver fibrogenesis-linked HCC.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0052554