A convenient synthesis of condensed thiazoles as promising tubulin/Tdp-1 bi-inhibitors

New derivatives of 5-bromo-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)cyclopent-2-enone in combination with different derivatives of aromatic aldehydes have been proposed as potential Tubulin/Tdp1 inhibitors. Precursors for cyclopentadienothiazole condensation were obtained by described in litera...

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Bibliographic Details
Main Authors: Mavlianberdiev, A. R., Yadykov, A. V., Shirinian, V. Z., Kolotaev, A. V., Osipov, V. N., Matevosyan, K. R., Khachatryan, D. S.
Format: Conference Proceeding
Language:English
Subjects:
Aldehydes
Inhibitors
NMR
Nuclear magnetic resonance
Online Access:Get full text
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Summary:New derivatives of 5-bromo-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)cyclopent-2-enone in combination with different derivatives of aromatic aldehydes have been proposed as potential Tubulin/Tdp1 inhibitors. Precursors for cyclopentadienothiazole condensation were obtained by described in literature methods with yields of 55- 86% and were characterized by 1H NMR spectra.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0069495