Evaluation of serum osteopontin and its relation with other biomarkers of prostate cancer in Iraqi patients

• Published in: AIP conference proceedings 2022-07, Vol.2450 (1)
• Main Authors: Al-Wadi, Ahmad H., Al-A’Araji, Sanad B., Ali, Susan J., Noor, Nawar A. Abd
• Format: Article
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0095584

Prostate Cancer (PC) is a worldwide common men’s cancer. Osteopontin OPN is a sialoprotein that helps to reconstruct bone tissue, its overexpressed in malignant. OPN is a promising PC diagnostic biomarker. the current study sought to determine the relationship between OPN levels and other biomarkers such as sex hormones, lipid profile (LP) , and renal function test (RFT) in PC Iraqi patients. The study included 80 patients (ranging in age from 49 to 83 years) divided into four groups, each with twenty patients. The patients were classified according to disease stages by consulting medical professionals, while 40 apparently healthy participants served as controls (according to age with a range of 45 to 80 years). in the span of many months, January 2020 to April 2020, blood samples were collected from patients at Oncology Teaching Hospital in Medical City in Baghdad. parameters biochemical OPN, sex hormones (Testosterone, Progesterone, Estradiol, and Prolactin), Lipid Profile LP (Cholesterol, Triglyceride, HDL, LDL, and VLDL), and RFT (Urea and Creatinine) levels were determined in patients and controls, and then a correlation between OPN levels and sex hormones, LP, and RFT biomarkers was established. the results of this study revealed a significant increase in OPN, sex hormones (Progesterone, Estradiol, and Prolactin), LP (Cholesterol, Triglyceride, LDL, and VLDL), and RFT (Urea and Creatinine) levels, whereas testosterone hormone and HDL levels were significantly decrease in PC patients compared to controls, Correlation between OPN with sex hormones (Progesterone, Estradiol, and Prolactin), LP(Cholesterol, Triglyceride, LDL, and VLDL), and RFT (Urea and Creatinine) was positive. while it was negative with testosterone hormone and HDL. the study came to the conclusion that OPN has a strong association with Urea, LDL, and testosterone hormone.