Synthesis new indole Schiff bases and evaluation their cytotoxicity against HepG2 and SK-GT2 cell line

Two new Schiff Bases successfully synthesized from reaction of 2-(5-Fluror-3, 3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde (2) with 2,4-dichloro aniline and 2-methyl aniline. The chemical structures of the new Schiff Bases were identifying by spectroscopic methods like, (FT-IR, 1H-NMR and A...

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Bibliographic Details
Main Authors: Hasan, Atared Salih, Faraj, Fadhil Lafta, Imran, Nuha A., Mohamed, Ibrahim hadi, Abdulateef, Maryam Hekmat
Format: Conference Proceeding
Language:English
Subjects:
Aniline
Biological activity
Chemical synthesis
Imines
NMR
Nuclear magnetic resonance
Toxicity testing
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Summary:Two new Schiff Bases successfully synthesized from reaction of 2-(5-Fluror-3, 3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde (2) with 2,4-dichloro aniline and 2-methyl aniline. The chemical structures of the new Schiff Bases were identifying by spectroscopic methods like, (FT-IR, 1H-NMR and APT 13C-NMR). The biological applications of new compounds were tested for their cytotoxicity activity against breast cancer cell line type HepG2 and SK-GT2 with different concentrations. The biological activity test shown that the synthesized Schiff Bases have promising cytotoxicity activity against HepG2 and SK-GT2 cell line.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0105400