Development of herbal doped electrospunmat for hemorrhoids

Electrospinning is a very simple and versatile process by which polymer nanofibers with diameters ranging from a few nanometers to several micrometers (usually between 50 and 500 nm) can be produced using an electrostatically driven jet of polymer solution (or polymer melt). Hemorrhoids, also referr...

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Bibliographic Details
Main Authors: Saravanan, M., Elakkiya, K.
Format: Conference Proceeding
Language:English
Subjects:
Biocompatibility
E coli
Electrospinning
Emission analysis
Field emission microscopy
Fourier transforms
Hemorrhoids
Irritation
Micrometers
Microorganisms
Nanofibers
Polymer melts
Polymers
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Summary:Electrospinning is a very simple and versatile process by which polymer nanofibers with diameters ranging from a few nanometers to several micrometers (usually between 50 and 500 nm) can be produced using an electrostatically driven jet of polymer solution (or polymer melt). Hemorrhoids, also referred as piles are a pathological condition occurring at the anorectal region. Nearly three out of four adults will have hemorrhoids from time to time. Aim of this work was to develop a herbal doped electrospun mat to treat hemorrhoids. The electrospun mat was incorporated with herbal called Solanum Torvum which has anti-bacterial and anti-microbial properties. With the sample electrospun mats produced, analysis have been made whether they provide relief from burning and irritation that are caused by hemorrhoids with some important basic tests. The morphology property of herbal doped electrospun PVA were characterised by FESEM (Field Emission Scanning Electron Microscope), FTIR (Fourier-Transform Infrared Spectroscopy) mainly, to investigate the physicochemical properties of electrospun nanofibres. Anti-bacterial activity of herbal doped electrospun nanofibres against E.coli and S.aureus showed excellent activity. Invitro dissolution method was used for drug release analysis. The drug release at 24hrs and 48 hrs and 72 hrs was found to be increasing gradually at sustained and constant rate. In-vitro biocmpatability of polymeric components are evaluated using MTT(3-[4,5-dimethylthiazolyl-2]-2,5-diphenyl tetrazolium bromide) assay. Here the drug concentration did not inhibit the growth of cells which shows the herbal doped electrospun nanofibres is biocompatible.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0108143