Effect of zinc oxide nanoparticles on activity of skin cancer cell line (A-375)

The widespread spread of skin cancer all over the world was impulse to researchers for trying the discovery of effective drugs including detection of the nanomaterial that contribute to its elimination. Zinc Oxide Nanoparticles (ZnO-NPs) were prepared by chemical lysis and sol-gel method and then ex...

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Bibliographic Details
Main Authors: Abdul Latif, Basem Mohamed, Mahdi Alzubaidy, Mohanad W.
Format: Conference Proceeding
Language:English
Subjects:
Cancer
Cytotoxicity
Electron microscopes
Nanomaterials
Nanoparticles
Skin cancer
Sol-gel processes
Toxicity
Zinc oxide
Zinc oxides
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Summary:The widespread spread of skin cancer all over the world was impulse to researchers for trying the discovery of effective drugs including detection of the nanomaterial that contribute to its elimination. Zinc Oxide Nanoparticles (ZnO-NPs) were prepared by chemical lysis and sol-gel method and then examined by X-ray diffraction and using scanning electron microscope (SEM). Cytotoxicity assays were also examined ex vivo to determine the toxic effect of ZnO-NPs at different concentrations (6.25-100 µg/ml) on melanoma cells using the cancer line A-375, and compared it with the normal line Human foreskin fibroblast cells (HFF). The obtained results were within the nanoscale, spherical shape, and size ranged between (37-62 nm). In addition, the cytotoxicity results showed the presence of an inhibitory activity affecting the growth of cancer cells, and there were no significant differences when exposed to ZnO-NPs on the normal line HFF. From the above, we conclude that there are promising results for a successful treatment to eliminate skin cancer using ZnO-NPs as an unconventional material used in cancer treatment.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0112679