Synthesis, characterization, and antimicrobial of [Ni(2-ampy)2(dca)2]

• Main Authors: Laksmana, Sutandyo Dwija, Wijaya, Husni Wahyu, Dasna, I. Wayan
• Format: Conference Proceeding
• Language: English
• Subjects: Aromatic compounds; Bacteria; Chloromycetin; Complex compounds; Infrared analysis; Ligands; Melting points; Pressure; Synthesis
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0112711

The Ni(2-ampy)2[N(CN)2]2 complex has been successfully synthesized using the reflux method and has been characterized. The complex (blue cubic) was characterized by melting point, FTIR, and XRD tests. Melting point measurement gave 245oC at ambient pressure and the colour turned from blue to green. FT-IR analysis indicated some vibrations of 2-aminopyridine and dicyanamide at 437(C-NH2 in-plane), 854 (aromatic ring), 1612, 1631 (C=C); 1448 (C-H) in-plane, (C=N): 2154, 2185 (vs), 2252 (ms) cm−1 which were unique for the coordination of both ligands to the nickel site. The results of XRDP analysis showed that this compound is isostructural with a Co(2-ampy)2[N(CN)2]2 complex, which has an octahedral geometry. The antibacterial activity was carried out by diffusion technique using Staphylococcus Aureus and Salmonella Typhi bacteria and chloramphenicol and ligands were used as reference. The bioactivity test results showed that 2-aminopyridine had the highest inhabitation zone S. typhi bacteria and the highest S. aureus was crystal samples. These differences provide an early picture of the antibacterial properties for S. typhi produced from the 2-aminopyridine ligand, while in S. aureus, it is produced from its own complex compound. The as-synthesized complex has the potential as an antibacterial agent.