PTEN promoter methylation study in West Sumatera breast cancer patients

DNA methylation of Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) promoter reported involved in breast tumorigenesis and tumor progression. This present study investigates methylation in PTEN promoters in West Sumatera Breast cancer patients and determines the association of PTEN pro...

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Bibliographic Details
Main Authors: Desriani, Azamris, Dermawan, Bagus, Thaharah, Alza Kirana, Irnidayanti, Yulia
Format: Conference Proceeding
Language:English
Subjects:
Breast cancer
DNA methylation
Metastasis
Parameters
Polymerase chain reaction
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Summary:DNA methylation of Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) promoter reported involved in breast tumorigenesis and tumor progression. This present study investigates methylation in PTEN promoters in West Sumatera Breast cancer patients and determines the association of PTEN promoter methylation with some clinicopathological parameters. A total of 36 breast cancer samples were examined, PTEN promoter methylation status was determined with a methylation-specific polymerase chain reaction. Further, this molecular finding that correlated with clinicopathological parameters (stage, metastatic, and age) was analyzed with SPSS software version 17 through Fisher's Test. This study detected PTEN promoter methylation in 19,44%, and 80,56% was detected as unmethylated. PTEN promoter methylation correlates with patients age (P= 0,029), and shown no correlation with carcinoma stage (P=0,63) and metastatic (P= 1,000). Since the sample used in this study were limited, it needs more sample and more complete clinicopathological parameter for more understanding of PTEN methylation in West Sumatera breast cancer patients.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0118515