Anti-cancer activity of silver nanoparticles and Staphylococcus aureus derived extracellular vesicles combination on malignant MCF-7 and non-malignant HBL-100 cell lines: In vitro study

Gram-positive extracellular vesicles have attracted interest as non-living complex vaccinations or delivery vehicles. However, no research has yet exploited extracellular vesicles to treat cancer. In this study, we look into the possibility of using bacterial membrane vesicles in combination with si...

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Bibliographic Details
Main Authors: Jasem, Meroj A., Alwan, Ali Hussain, Hamed, Saad L.
Format: Conference Proceeding
Language:English
Subjects:
Anticancer properties
Membranes
Nanoparticles
Silver
Toxicity
Vesicles
Online Access:Get full text
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Summary:Gram-positive extracellular vesicles have attracted interest as non-living complex vaccinations or delivery vehicles. However, no research has yet exploited extracellular vesicles to treat cancer. In this study, we look into the possibility of using bacterial membrane vesicles in combination with silver nanoparticles to treat cancer. Our findings demonstrate that the combination of bacterial membrane vesicles and AgNps can efficiently elicit selective cytotoxicity in the breast cancer cell line MCF-7 antitumor without causing significant cytotoxicity in the human epithelial breast tissue cell line HBL-100.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0119343