Characterization of natural halal hydroxyapatite (HAp) from black tilapia fish scale for biomedical application

Since the hydroxyapatite derived from the Black Tilapia fish scale (BTFS) is less expensive and easier to obtain than synthetic hydroxyapatite and is safer than animal-derived hydroxyapatite such as bones, the fish scales were used as a source of natural halal hydroxyapatite (HAp). This work investi...

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Main Authors: Jaffri, Muhamad Zaki, Ismail, Zamratul Maisarah Mohd, Dermawan, Siti Khadijah, Pu’ad, Nor Atiqah Syafinaz Mohd, Idris, Maizlinda Izwana, Chuan, Lee Te, Abdullah, Hasan Zuhudi
Format: Conference Proceeding
Language:English
Subjects:
Apatite
Bacteria
Bathing
Biomedical materials
Body fluids
Bones
Fish
Hydroxyapatite
Particle shape
Roasting
Scanning electron microscopy
Sharks
Tilapia
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Summary:Since the hydroxyapatite derived from the Black Tilapia fish scale (BTFS) is less expensive and easier to obtain than synthetic hydroxyapatite and is safer than animal-derived hydroxyapatite such as bones, the fish scales were used as a source of natural halal hydroxyapatite (HAp). This work investigates the preparation and synthesis of natural halal hydroxyapatite from black tilapia fish scales by grinding and crushing aided by a mechanical crusher in order to produce a microscopic and fine hydroxyapatite powder using a thermal calcination technique aided by a furnace. The crystalline phase and existence of hydroxyapatite were verified and described using X-ray diffraction (XRD) in this research and the morphology of the hydroxyapatite powders was investigated using scanning electron microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). SEM results revealed the hexagonal particle shape obtained from natural halal hydroxyapatite powder. In Addition, in bioactivity evaluation also strengthens the development of bone like apatite on the pallet surface after 14 days of Simulated Body Fluid (SBF) bathing or immersion. The antibacterial activity of the samples was tested using the well diffusion method against two pathogenic bacteria, gram-positive and gram-negative bacterial strains, resulting in there is no antibacterial properties in the BTFS HAp samples. With some enhancements that could be made by future investigations, this capacity presents promising value to the calcined BTFS HAp samples for bio-medical use in the biological field.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0121624