Gene expression of Caspase-9 and Calm1 in rat models of Alzheimer’s disease after addition Mesenchymal Stem Cell Wharton Jelly

Dementia is a chronic or progressive syndrome characterized by impaired cognitive capacity from Alzheimer’s disease in which the expression of the Caspase-9 and Calm1 genes is one of the genes that play a role in this disease. This study aims to see gene expression of Caspase-9 and Calm1 in rat mode...

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Bibliographic Details
Main Authors: Ali, Hirowati, Tjong, Djong Hon, Yarni, Sisca Dwi
Format: Conference Proceeding
Language:English
Subjects:
Aluminum chloride
Alzheimer's disease
Apoptosis
Gene expression
Genes
Health services
Stem cells
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Summary:Dementia is a chronic or progressive syndrome characterized by impaired cognitive capacity from Alzheimer’s disease in which the expression of the Caspase-9 and Calm1 genes is one of the genes that play a role in this disease. This study aims to see gene expression of Caspase-9 and Calm1 in rat models of Alzheimer’s disease after the addition of Mesenchymal Stem Cell Wharton Jelly (MSC-WJ). The treatment group consisted of a control, AlCl3, MSC-WJ, and a combination of AlCl3 and MSC-WJ. All treatment groups were tested using the Realtime PCR (RT-PCR) method. All experimental groups were analyzed using the one-way ANOVA test using SPSS. If the p-value
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0128171