Computational model based approach to analyze pacemaking activity of sinoatrial node due to calcium channels using Runge Kutta method

• Main Authors: Yamuna, D., Ramaswamy, Arulvel, Gulothungan, G.
• Format: Conference Proceeding
• Language: English
• Subjects: Calcium; Electrocardiography; Heart function; Membranes; Prolongation; Runge-Kutta method; Waveforms
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0174336

To investigate the calcium particle membrane potential to divert impacts in atrial node Electrocardiogram (ECG) age for the ordinary and unusual condition utilizing Rungekutta technique. In this research human atrial cells are based on [1] method can be used to describe the action potential model of sinoatrial nodes. Sample size can be calculated as 70 and the G power is 80%. The normal membrane potential of calcium is -30 mV, but for the different abnormal values that is increasing of 100%, 50% and 25% of the membrane potentials are -52mV, -26mV and -42mV and then the decreasing of 100% and 50% calcium levels does not form single ECG waveform, decreasing of 25%, the membrane potential is - 45mV which having the mean value range of 7mV to 17mV. By comparing these values there is a difference in peacemaking activity and causes irregular heart beat and prolongation occurs. In normal Action potential, the contraction will occur regularly. In abnormal AP, the conduction of electrical excitation will differ and make irregular heart function cause arrhythmia. In the future, a better understanding of the cellular model can be used to detect the drug that helps to make a normal heart beat.