Prediction of heat distribution on brain malignant tumor using hyperthermia therapy

• Main Authors: Kamarudin, Saddam, Taib, Ishkrizat, Adnan, Maliki, Nasir, Fitriah, Ariffin, Ahmad Mubarak Tajul, Salim, Nor Adrian Nor, Darlis, Nofrizal Idris, Abdullah, Mohd Noor, Kamil, Ali
• Format: Conference Proceeding
• Language: English
• Subjects: Brain; Brain cancer; Brain research; Fever; Heat; Heat distribution; Heat generation; Hyperthermia; Side effects; Simulation; Temperature; Tumors
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0183646

The malignant brain tumor is cancer which is not controlled by the cells of the brain and which produces new cells until normal cells are overwhelmed and body system problems are caused. There are several treatments that people normally do, but it has a side effect on the body. Based on the previous study, hyperthermia is a treatment that can reduce the size of tumor with less side effects to the surrounding tissue. The method of hyperthermia treatment is applied to this study which is the heat is applied to the tumor with a certain temperature and time treatment. This research focuses on heat distribution to different temperatures of malignant brain tumors. Other’s thing that needs to find out is the comparison of heat distribution of brain tumor for different temperatures with different depths of tumor inside the brain. The CFD is applied in these cases and Ansys software is used to run the simulation. The heat source used in this study is infrared. For all simulations, the time considered is 500 seconds and a time step were 0.1 seconds. From the result obtained, the tumor temperature increases due to the increasing of temperature that is applied to the skin from the heat source. For the different positions of tumor, the heat was not penetrated well due to the depth of the tumor inside the brain. The temperature also needs to rise up if the tumor were growing deep inside the brain but it needs some study on temperature and time of treatment that want to used. The size of the tumor did not affect the temperature of the tumor, as the simulation results demonstrated that the temperature remained constant but the position depth of tumor gives the biggest effect on heat penetration. The heat generation of the tumor has affected the temperature that comes out from the tumor. This research study also helps the medical expert in improving the efficiency of the treatment based on heat distribution with different temperatures.