Cashew leaf extract gel as antibacterial with CMC-Na as gelling agent

• Main Authors: Chabib, Lutfi, Hartanto, Syukri, Yandi, Suryani, Arman
• Format: Conference Proceeding
• Language: English
• Subjects: Adhesion tests; Antiinfectives and antibacterials; Carboxymethyl cellulose; Carrier density; Ethanol; Flavonoids; Formulations; Homogeneity; Viscosity
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0205318

The ethanol extract of cashew leaves has very strong antibacterial substances such as flavonoids, tannins, and triterpenoids. The purpose of this study was to examine the optimal viscosity of the cashew leaf extract gel preparation with variations in the concentration of CMC-Na as a gelling agent. Extraction of cashew leaves using maceration method using 70% ethanol for 2 days. The characterization of the gel preparations observed included viscosity tests, pH tests, homogeneity tests and microbiological tests. The best viscosity is shown by formula 2 with a value of 259.067 Cpas which is neither too runny nor too thick. Testing the pH of the three formulations of the cashew extract gel, the pH value was almost the same as the average pH of 4.45. The results of testing the stickiness of the cashew leaf gel preparation obtained a low value below 0.00081 cm/second, the adhesion test was carried out to find out how long the preparation could stick to the surface of the skin, the higher the stickiness the more drug was absorbed into the skin. The results of the particle size test of formula 2 have the smallest size of 142.20 m ± 0.297 with the smallest measurement difference which shows that formula 2 is more homogeneous than the other formulas. The results of the microbiological test showed good inhibition in formula 1 with an average value of 16.55 mm ± 1.909 and formula 2 with an average value of 16.30 mm ± 2.546. This result is a strong inhibitory ability of the test. In conclusion, the concentration of carboxymethylcellulose in formulation 2 has better characteristics as a carrier for cashew leaf extract and is effective in inhibiting bacteria classified as strong antibacterial.