Nanocomposites in drug delivery: Advancements and applications

• Main Authors: Thakre, Divya, Vaidya, Sunita, Agrawal, Surendra, Waghe, Prajakta
• Format: Conference Proceeding
• Language: English
• Subjects: Computed tomography; Diagnostic software; Drug carriers; In vivo methods and tests; Magnetic resonance imaging; Nanocomposites; Nanomaterials; Solubility; Target detection
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0240242

The production and application of nanomaterials have recently witnessed significant progress, offering a comprehensive approach to detecting and treating various ailments. In summary, the structural framework and geometric characteristics of bioinspired nanocarriers play a crucial role in influencing the overall properties of the encapsulated drug at the molecular and atomic levels. This modulation enables the nanocarriers to effectively and predictably target specific disease sites, thereby influencing both pathological conditions and abnormal metabolic states in a desired manner. From a pharmacotechnical standpoint, bioinspired nanotechnological processes are advantageous in facilitating the use of carriers to enhance the solubility of medications with poor water solubility. Additionally, these techniques enable the achievement of well-regulated sustained-release profiles, hence reducing the need for frequent drug therapy. Therefore, from a biopharmaceutical standpoint, these nanocomposites have the dual advantage of reducing first-pass metabolism and enhancing biodistribution, permeability, adhesion, and diffusivity in vivo. In contrast to the considerations mentioned above, it is noteworthy that nanocomposites are significant in diagnosis and therapy. The diagnostic center conducts an analysis of contemporary advancements and innovations in diagnostic tools and methodologies for the identification of previously unidentified diseases. These tools, including computed tomography, magnetic resonance imaging, and others, rely significantly on nanocomposites. This study looks at how nanocomposites have changed how drugs are given and how they can be used. It details the different kinds of nanocomposites, how they are made, and how they help improve how drugs are given and how well they work.