Analog implementation of a Hodgkin–Huxley model neuron

We construct an electronic circuit for mimicking a single neuron's behavior in connection with the dynamics of the Hodgkin–Huxley mathematical model. Our results show that the electronic neuron, even though it contains binary-state circuitry components, displays a timing interplay between the i...

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Bibliographic Details
Published in:American journal of physics 2020-11, Vol.88 (11), p.918-923
Main Authors: Rutherford, George H., Mobille, Zach D., Brandt-Trainer, Jordan, Follmann, Rosangela, Rosa, Epaminondas
Format: Article
Language:English
Subjects:
Circuits
Electronics
Ions
Mathematical models
Neurophysiology
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Summary:We construct an electronic circuit for mimicking a single neuron's behavior in connection with the dynamics of the Hodgkin–Huxley mathematical model. Our results show that the electronic neuron, even though it contains binary-state circuitry components, displays a timing interplay between the ion channels, which is consistent with the corresponding timing encountered in the model equations. This is at the core of the mechanism determining not only the creation of action potentials but also the neuronal firing rate output. This work is suitable for educational purposes in physics, mathematical modeling, electronics, and neurophysiology and can be extended for implementation in networked neurons for more advanced studies of neuronal behaviors.
ISSN:0002-9505
1943-2909
DOI:10.1119/10.0001072