Diffusion model for ultrasound-modulated light

Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US-optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equat...

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Bibliographic Details
Published in:Journal of biomedical optics 2014-03, Vol.19 (3), p.035005-035005
Main Authors: Hollmann, Joseph L, Horstmeyer, Roarke, Yang, Changhuei, DiMarzio, Charles A
Format: Article
Language:English
Subjects:
Approximation
Computer Simulation
Diffusion
Finite difference method
Green's functions
Light
Mathematical analysis
Models, Theoretical
Phantoms, Imaging
Reflectivity
Scattering
Scattering, Radiation
Ultrasonics
Ultrasound
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Summary:Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US-optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equation is employed to develop a Green's function for US-modulated light. The predicted modulated fluence and flux are verified using finite-difference time-domain simulations. The Green's function is then utilized to illustrate the modulated reflectance as the US-optical interaction increases in depth. The intent of this paper is to focus on high US frequencies necessary for high-resolution imaging because they are of interest for applications such as phase conjugation.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.19.3.035005