Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling

Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adv...

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Bibliographic Details
Published in:Journal of biomedical optics 2015-05, Vol.20 (5), p.058001-058001
Main Authors: Vignion-Dewalle, Anne-Sophie, Betrouni, Nacim, Tylcz, Jean-Baptiste, Vermandel, Maximilien, Mortier, Laurent, Mordon, Serge
Format: Article
Language:English
Subjects:
Aminolevulinic Acid - administration & dosage
Cancer
Computer Simulation
Dose-Response Relationship, Radiation
Humans
Keratosis, Actinic - drug therapy
Keratosis, Actinic - physiopathology
Life Sciences
Light
Models, Biological
Photochemotherapy - methods
Photosensitizing Agents - administration & dosage
Radiation Dosage
Skin - drug effects
Skin - physiopathology
Skin - radiation effects
Therapy, Computer-Assisted - methods
Treatment Outcome
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Summary:Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adverse effects or to expand the use of PDT, are still being evaluated and refined. We propose a comparison of the three most common light doses in the treatment of actinic keratosis with 5-aminolevulinic acid PDT through mathematical modeling. The proposed model is based on an iterative procedure that involves determination of the local fluence rate, updating of the local optical properties, and estimation of the local damage induced by the therapy. This model was applied on a simplified skin sample model including an actinic keratosis lesion, with three different light doses (red light dose, 37  J/cm2, 75  mW/cm2, 500 s; blue light dose, 10  J/cm2, 10  mW/cm2, 1000 s; and daylight dose, 9000 s). Results analysis shows that the three studied light doses, although all efficient, lead to variable local damage. Defining reference damage enables the nonoptimal parameters for the current light doses to be refined and the treatment to be more suitable.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.20.5.058001