In vivo reflectance-mode confocal microscopy assessments: impact of overweight on human skin microcirculation and histomorphology

Reflectance-mode confocal microscopy (RCM) enables in vivo assessment of the human skin. Impact of overweight on both human skin microcirculation and histomorphology has not been investigated in vivo. The purpose of this study is to evaluate both microcirculation and histomorphology in vivo in overw...

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Bibliographic Details
Published in:Journal of biomedical optics 2016-03, Vol.21 (3), p.036009-036009
Main Authors: Altintas, Ahmet A, Aust, Matthias C, Krämer, Robert, Vogt, Peter M, Altintas, Mehmet A
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Male
Microcirculation - physiology
Microscopy, Confocal - methods
Middle Aged
Overweight - diagnostic imaging
Skin - blood supply
Skin - diagnostic imaging
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Summary:Reflectance-mode confocal microscopy (RCM) enables in vivo assessment of the human skin. Impact of overweight on both human skin microcirculation and histomorphology has not been investigated in vivo. The purpose of this study is to evaluate both microcirculation and histomorphology in vivo in overweight. In 10 normotensive overweight nondiabetic individuals (OW-group, BMI 29.1±2.7  kg/m2) and 10 age- and sex-matched healthy lean controls (CO-group, BMI 20.4±1.9  kg/m2) the following parameters were evaluated using RCM: dermal blood cell flow (DBCF), density of dermal capillaries (DDC), epidermal thickness (ET), and epidermal cell size (ECS). DBCF was counted at 63.11±4.14  cells/min in OW-group and at 51.06±3.84  cells/min in CO-group (P
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.21.3.036009