Characterization of lipid-rich plaques using spectroscopic optical coherence tomography

Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic a...

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Bibliographic Details
Published in:Journal of biomedical optics 2016-07, Vol.21 (7), p.075004-075004
Main Authors: Nam, Hyeong Soo, Song, Joon Woo, Jang, Sun-Joo, Lee, Jae Joong, Oh, Wang-Yuhl, Kim, Jin Won, Yoo, Hongki
Format: Article
Language:English
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Summary:Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.21.7.075004