Assessing the relationship between the cerebral metabolic rate of oxygen and the oxidation state of cytochrome-c-oxidase

Significance: Hyperspectral near-infrared spectroscopy (hsNIRS) combined with diffuse correlation spectroscopy (DCS) provides a noninvasive approach for monitoring cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO2) and the oxidation state of cytochrome-c-oxidase (oxCCO). CMRO2...

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Bibliographic Details
Published in:Neurophotonics (Print) 2022-07, Vol.9 (3), p.035001-035001
Main Authors: Milej, Daniel, Rajaram, Ajay, Suwalski, Marianne, Morrison, Laura B., Shoemaker, Leena N., St. Lawrence, Keith
Format: Article
Language:English
Subjects:
Blood flow
Blood pressure
Cerebral blood flow
Cytochrome
Cytochrome c
Data analysis
Experiments
Hemoglobin
Hypoxia
Infrared spectroscopy
Ischemia
Light
Medical research
Metabolic rate
Metabolic response
Metabolism
Oxidation
Oxygen
Oxygen saturation
Research Papers
Sensors
Spectrum analysis
Traumatic brain injury
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Summary:Significance: Hyperspectral near-infrared spectroscopy (hsNIRS) combined with diffuse correlation spectroscopy (DCS) provides a noninvasive approach for monitoring cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO2) and the oxidation state of cytochrome-c-oxidase (oxCCO). CMRO2 is calculated by combining tissue oxygen saturation (StO2) with CBF, whereas oxCCO can be measured directly by hsNIRS. Although both reflect oxygen metabolism, a direct comparison has yet to be studied. Aim: We aim to investigate the relationship between CMRO2 and oxCCO during periods of restricted oxygen delivery and lower metabolic demand. Approach: A hybrid hsNIRS/DCS system was used to measure hemodynamic and metabolic responses in piglets exposed to cerebral ischemia and anesthetic-induced reductions in brain activity. Results: Although a linear relationship was observed between CMRO2 and oxCCO during ischemia, both exhibited a nonlinear relationship with respect to CBF. In contrast, linear correlation was sufficient to characterize the relationships between CMRO2 and CBF and between the two metabolic markers during reduced metabolic demand. Conclusions: The observed relationship between CMRO2 and oxCCO during periods of restricted oxygen delivery and lower metabolic demand indicates that the two metabolic markers are strongly correlated.
ISSN:2329-423X
2329-4248
DOI:10.1117/1.NPh.9.3.035001