Morphofunctional Evaluation of the Effect of Transplantation of Allogeneic Fibroblasts on Healing of Burn Wounds in Albino Outbred Mice and Mutant Hrhr/Hrhr Mice

Morphofunctional evaluation of the effect of transplantation of allogeneic fibroblasts on skin regeneration after burn injury in albino outbred mice and mutant Hr hr / Hr hr (nude) mice was carried out using the radioautographic method. The pronounced stimulating effect of allogeneic fibroblasts on...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012, Vol.152 (4), p.535-542
Main Authors: Kolokolchikova, E. G., Zhirkova, E. A., Golovatenko-Abramov, P. K., Platonov, E. S., Smirnov, S. V., Botcharova, V. S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Summary:Morphofunctional evaluation of the effect of transplantation of allogeneic fibroblasts on skin regeneration after burn injury in albino outbred mice and mutant Hr hr / Hr hr (nude) mice was carried out using the radioautographic method. The pronounced stimulating effect of allogeneic fibroblasts on healing of burn wound observed in mice of both groups can be attributed to the action of bioactive substances released from destructed allogeneic fibroblasts and stimulating proliferation of stem/progenitor cells in the wound (epithelial cells in skin appendages and dermal cells in microvessel walls) at the early stages of healing.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1570-6