Intranasally administered Lactobacillusgasseri TMC0356 protects mice from H1N1 influenza virus infection by stimulating respiratory immune responses

We conducted a study to evaluate the possibility that intranasal administration of a new probiotic strain Lactobacillus gasseri TMC0356 (TMC0356) may protect host animals from influenza virus (IFV) infection, which was indicated by enhanced respiratory immune responses in a mouse model. After 3 days...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2011, Vol.27 (2), p.411-416
Main Authors: Harata, Gaku, He, Fang, Hiruta, Naoyuki, Kawase, Manabu, Kubota, Akira, Hiramatsu, Masaru, Yausi, Hisako
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Environmental Engineering/Biotechnology
Life Sciences
Microbiology
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Summary:We conducted a study to evaluate the possibility that intranasal administration of a new probiotic strain Lactobacillus gasseri TMC0356 (TMC0356) may protect host animals from influenza virus (IFV) infection, which was indicated by enhanced respiratory immune responses in a mouse model. After 3 days of exposure to TMC0356, BALB/c mice were intranasally infected with IFVA/PR/8/34 (H1N1). Lung cells were isolated from the tested mice and evaluated for cytotoxicity against YAC-1 cells. After intranasal treatment with TMC0356, mice showed a lower morbidity and higher survival rate compared to control mice ( P  
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-010-0472-x