Flaxseed Bioactive Compounds and Colorectal Cancer Prevention

Purpose of Review Flaxseed and its bioactive components have been associated with a decreased risk of colorectal cancer incidence and progression. This review aims to summarize recent research regarding the role of flaxseed and each of its major dietary bioactive components in reducing colorectal ca...

Full description

Saved in:
Bibliographic Details
Published in:Current oncology reports 2018-08, Vol.20 (8)
Main Authors: DeLuca, Jennifer A. A., Garcia-Villatoro, Erika L., Allred, Clinton D.
Format: Article
Language:English
Subjects:
Integrative Care (C Lammersfeld
Medicine
Medicine & Public Health
Oncology
Section Editor
Topical Collection on Integrative Care
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review Flaxseed and its bioactive components have been associated with a decreased risk of colorectal cancer incidence and progression. This review aims to summarize recent research regarding the role of flaxseed and each of its major dietary bioactive components in reducing colorectal cancer. Recent Findings In both human and animal model experiments, flaxseed consumption had beneficial effects on colon physiology associated with reduction in colorectal cancer risk or occurrence. Considered separately, each of flaxseed’s major bioactive components, including fiber, alpha-linolenic acid, lignans, and other phytochemicals, is also associated with decreased risk of colonic neoplasms and regulation of cell growth through several potential mechanisms. Summary Collectively, experimental data suggests that consumption of flaxseed and/or its bioactive components may reduce colorectal cancer risk by a variety of mechanisms. Future studies should focus on the mechanisms by which whole flaxseed can prevent colorectal cancer.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-018-0704-z