Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei: Y. Hu et al.: Neural Network Mechanisms Underlying General Anesthesia

General anesthesia plays a significant role in modern medicine. However, the precise mechanism of general anesthesia remains unclear, posing a key scientific challenge in anesthesiology. Advances in neuroscience techniques have enabled targeted manipulation of specific neural circuits and the captur...

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Bibliographic Details
Published in:Neuroscience bulletin 2024, Vol.40 (12), p.1995-2011
Main Authors: Hu, Yue, Wang, Yun, Zhang, Lingjing, Luo, Mengqiang, Wang, Yingwei
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Human Physiology
Neurology
Neurosciences
Pain Medicine
Review
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Summary:General anesthesia plays a significant role in modern medicine. However, the precise mechanism of general anesthesia remains unclear, posing a key scientific challenge in anesthesiology. Advances in neuroscience techniques have enabled targeted manipulation of specific neural circuits and the capture of brain-wide neural activity at high resolution. These advances hold promise for elucidating the intricate mechanisms of action of general anesthetics. This review aims to summarize our current understanding of the role of cortical and subcortical nuclei in modulating general anesthesia, providing new evidence of cortico-cortical and thalamocortical networks in relation to anesthesia and consciousness. These insights contribute to a comprehensive understanding of the neural network mechanisms underlying general anesthesia.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-024-01286-z