An environmentally benign solvent/catalyst-free one-pot synthesis of N-substituted phthalimides via Aza-wittig reaction

For the first time an environmentally benign solvent/catalyst-free protocol for the synthesis of a variety of N -substituted phthalimides is submitted. It involves a one-pot coupling of nascent phosphazene generated in situ with phthalic anhydride. The protocol is novel in (1) avoiding toxic solvent...

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Bibliographic Details
Published in:Journal of the Iranian Chemical Society 2012-10, Vol.9 (5), p.681-685
Main Authors: Sathishkumar, Murugan, Palanikumar, Kulandaivel, Mariappan, Arumugam, Archana, Sivasubramaniyan, Ponnuswamy, Alagusundaram
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Chemistry
Chemistry and Materials Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
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Summary:For the first time an environmentally benign solvent/catalyst-free protocol for the synthesis of a variety of N -substituted phthalimides is submitted. It involves a one-pot coupling of nascent phosphazene generated in situ with phthalic anhydride. The protocol is novel in (1) avoiding toxic solvents, (2) no catalyst is employed and (3) no isophthalimide is formed as noted in the prevailing solution phase/catalysed methodology.
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-012-0090-7