UCNP@SiO2-maltotrios/HMME preparation and properties study

Bone and joint infections (BJI) are common diseases in the musculoskeletal system, posing significant challenges due to their difficult early diagnosis, prolonged treatment periods, high costs, and potential for severe consequences. Building upon our previous work on maltotriose-modified magnetite n...

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Bibliographic Details
Published in:Advanced composites and hybrid materials 2025-02, Vol.8 (1)
Main Authors: Yin, Chuqiang, Shen, Youliang, Wang, Wenqiao, Shen, Feng, Wang, Yuelei, Han, Zengshuai, Wang, Ting
Format: Article
Language:English
Subjects:
Ceramics
Chemistry and Materials Science
Composites
Glass
Materials Engineering
Materials Science
Natural Materials
Polymer Sciences
Online Access:Get full text
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Summary:Bone and joint infections (BJI) are common diseases in the musculoskeletal system, posing significant challenges due to their difficult early diagnosis, prolonged treatment periods, high costs, and potential for severe consequences. Building upon our previous work on maltotriose-modified magnetite nanoparticles (Fe 3 O 4 -maltotriose), we delve deeper into the research, incorporating the photosensitizer HMME. This integration enables targeted diagnosis of infectious lesions while simultaneously killing bacteria for therapeutic intervention. This study presents the development of a precision drug delivery system (UCNP@SiO 2 -maltotrios/HMME) for the treatment of bacterial infections in bones and joints. Through a microemulsion method, we encapsulated mesoporous SiO 2 onto the surface of upconversion nanoparticles (UCNPs). We then loaded the internal space with the photosensitizer porphyrin monomethyl ether (HMME) to release singlet oxygen ( 1 O 2 ) upon acoustic activation, and externally loaded maltotriose (maltotrios) as a targeting molecule. Our research investigates the HMME drug loading capacity, and singlet oxygen bactericidal capabilities of this material using a rat infection model. We further evaluated its bactericidal efficacy and biosafety through in vitro cell experiments and in vivo animal studies. Our results demonstrate the excellent luminescence properties and normal imaging capabilities of UCNP@SiO 2 -maltotrios/HMME both in vitro and in vivo. Notably, this material exhibits strong precision targeting and antibacterial activity against Escherichia coli and Staphylococcus aureus . Moreover, UCNP@SiO 2 -maltotrios/HMME demonstrates no cytotoxicity in cells or organs of mice, indicating its favorable biosafety. Graphical abstract
ISSN:2522-0128
2522-0136
DOI:10.1007/s42114-024-01096-x