Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies: Clinical Oncology/Epidemiology

Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and exten...

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Bibliographic Details
Published in:British journal of cancer 1993-07, Vol.68 (1), p.122-124
Main Authors: Banks, RE, Gearing, AJ, Hemingway, IK, Norfolk, DR, Perren, TJ, Selby, PJ
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
clinical-oncology-epidemiology
Drug Resistance
Epidemiology
Molecular Medicine
Oncology
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Summary:Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies reporting measurement of circulating ICAM-1. Soluble ICAM-1 and VCAM-1 levels were significantly higher in all the patient groups compared with the controls whereas soluble E-selectin was significantly higher in the ovarian, breast and GI cancer groups and lower in the myeloma group. The significance of these results together with the possible sources and stimuli for release of these adhesion molecules are discussed.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1993.298