The role of dendritic cell precursors in tumour vasculogenesis: Minireview

In this review, we discuss the recent identification in vivo of a population of CD11c + cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, ca...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2005-04, Vol.92 (7), p.1182-1187
Main Authors: Coukos, G, Benencia, F, Buckanovich, R J, Conejo-Garcia, J R
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Drug Resistance
Epidemiology
mini-review
Molecular Medicine
Oncology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this review, we discuss the recent identification in vivo of a population of CD11c + cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into functional blood vessels or act as antigen-presenting cells. The identification of dendritic cell precursors as bipotent cells has important implications for the physiopathology and therapy of tumours. VLCs emerge as a novel therapeutic target against tumour vascularisation.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602476