The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin

• Published in: Inorganic materials : applied research 2024-06, Vol.15 (3), p.842-850
• Main Authors: Lozhkomoev, A. S., Kazantsev, S. O., Bakina, O. V., Buyakov, A. S., Senkina, E. I., Krinitcyn, M. G., Ivanyuk, V. A., Sharipova, A. F., Lerner, M. I.
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Materials Science; New Methods of Treatment and Production of Materials with Required Properties
• ISSN: 2075-1133; 2075-115X
• DOI: 10.1134/S207511332470028X

— A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.