Effects of sympathetic stimulation on the rhythmical jaw movements produced by electrical stimulation of the cortical masticatory areas of rabbits

• Published in: Experimental brain research 2005-03, Vol.162 (1), p.14-22
• Main Authors: ROATTA, S, WINDHORST, U, DJUPSJÖBACKA, M, LYTVYNENKO, S, PASSATORE, M
• Format: Article
• Language: English
• Subjects: Action Potentials - physiology; Animals; Biological and medical sciences; Electric Stimulation; Electromyography; Fundamental and applied biological sciences. Psychology; Masseter Muscle - innervation; Masseter Muscle - physiology; Masseter Muscle innervation physiology; Mastication - physiology; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Motor Cortex - physiology; Muscle Contraction - physiology; Muscle Spindles - physiology; Neural Inhibition - physiology; Pain - etiology; Pain - physiopathology; Pain etiology physiopathology; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Postganglionic physiology; Psychological complications physiopathology; Pyramidal Tracts - physiology; Rabbits; Stress; Stress, Psychological - complications; Stress, Psychological - physiopathology; Sympathetic Fibers; Sympathetic Fibers, Postganglionic - physiology; Vertebrates: nervous system and sense organs
• ISSN: 0014-4819; 1432-1106; 1432-1106
• DOI: 10.1007/s00221-004-2102-z

The somatomotor and sympathetic nervous systems are intimately linked. One example is the influence of peripheral sympathetic fibers on the discharge characteristics of muscle spindles. Since muscle spindles play important roles in various motor behaviors, including rhythmic movements, the working hypothesis of this research was that changes in sympathetic outflow to muscle spindles can change rhythmic movement patterns. We tested this hypothesis in the masticatory system of rabbits. Rhythmic jaw movements and EMG activity induced by long-lasting electrical cortical stimulation were powerfully modulated by electrical stimulation of the peripheral stump of the cervical sympathetic nerve (CSN). This modulation manifested itself as a consistent and marked reduction in the excursion of the mandibular movements (often preceded by a transient modest enhancement), which could be attributed mainly to corresponding changes in masseter muscle activity. These changes outlasted the duration of CSN stimulation. In some of the cortically evoked rhythmic jaw movements (CRJMs) changes in masticatory frequency were also observed. When the jaw-closing muscles were subjected to repetitive ramp-and-hold force pulses, the CRMJs changed characteristics. Masseter EMG activity was strongly enhanced and digastric EMG slightly decreased. This change was considerably depressed during CSN stimulation. These effects of CSN stimulation are similar in sign and time course to the depression exerted by sympathetic activity on the jaw-closing muscle spindle discharge. It is suggested that the change in proprioceptive information induced by an increase in sympathetic outflow (a) has important implications even under normal conditions for the control of motor function in states of high sympathetic activity, and (b) is one of the mechanisms responsible for motor impairment under certain pathological conditions such as chronic musculoskeletal head-neck disorders, associated with stress conditions.