Attention and motor profiles in children with developmental coordination disorder: A neuropsychological and neuroimaging investigation

• Published in: Developmental medicine and child neurology 2024-03, Vol.66 (3), p.362-378
• Main Authors: Bonthrone, Alexandra F., Green, Dido, Morgan, Angela T., Mankad, Kshitij, Clark, Christopher A., Liégeois, Frédérique J.
• Format: Article
• Language: English
• Subjects: Attention Deficit Disorder with Hyperactivity - complications; Attention Deficit Disorder with Hyperactivity - diagnostic imaging; Brain - diagnostic imaging; Child; Cognition; Executive Function; Humans; Motor Skills; Motor Skills Disorders - psychology; Neuroimaging; Original
• ISSN: 0012-1622; 1469-8749; 1469-8749
• DOI: 10.1111/dmcn.15745

Aim This study aimed to (1) quantify attention and executive functioning in children with developmental coordination disorder (DCD), (2) assess whether some children with DCD are more likely to show attention difficulties, and (3) characterize brain correlates of motor and attention deficits. Method Fifty‐three children (36 with DCD and 17 without) aged 8 to 10 years underwent T1‐weighted and diffusion‐weighted magnetic resonance imaging, and standardized attention and motor assessments. Parents completed questionnaires of executive functioning and symptoms of inattention and hyperactivity. We assessed regional cortical thickness and surface area, and cerebellar, callosal, and primary motor tract structure. Results Analyses of covariance and one‐sample t‐tests identified impaired attention, non‐motor processing speed, and executive functioning in children with DCD, yet partial Spearman's rank correlation coefficients revealed these were unrelated to one another or the type or severity of the motor deficit. Robust regression analyses revealed that cortical morphology in the posterior cingulate was associated with both gross motor skills and inattentive symptoms in children with DCD, while gross motor skills were also associated with left corticospinal tract (CST) morphology. Interpretation Children with DCD may benefit from routine attention and hyperactivity assessments. Alterations in the posterior cingulate and CST may be linked to impaired forward modelling during movements in children with DCD. Overall, alterations in these regions may explain the high rate of non‐motor impairments in children with DCD. What this paper adds Children with developmental coordination disorder have difficulties in attention, processing speed, and executive functioning. Non‐motor impairments were not interrelated or correlated with the type or severity of motor deficit. Posterior cingulate morphology was associated with gross motor skills and inattention. Gross motor skills were also associated with left corticospinal tract morphology. What this paper adds Children with developmental coordination disorder have difficulties in attention, processing speed, and executive functioning. Non‐motor impairments were not interrelated or correlated with the type or severity of motor deficit. Posterior cingulate morphology was associated with gross motor skills and inattention. Gross motor skills were also associated with left corticospinal tract morphology. This original article is co