Thiol End-Functionalization of Poly(ε-caprolactone), Catalyzed by Candida antarctica Lipase B

The use of Candida antarctica Lipase B (CALB) chemoselective catalyst in the Thiol End-Functionalization of Poly(ε-caprolacetone) was discussed. Thiol-functionalization of poly(ε-caprolacetone)(PCL) was made by an initiation reaction catalyzed by CALB in bulk. 2-Mercaptoethanol (1) was used to initi...

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Bibliographic Details
Published in:Macromolecules 2005-02, Vol.38 (3), p.647-649
Main Authors: Hedfors, Cecilia, Östmark, Emma, Malmström, Eva, Hult, Karl, Martinelle, Mats
Format: Article
Language:English
Subjects:
Applied sciences
Biochemistry
Biokemi
Chemistry
epsilon-caprolactone
Exact sciences and technology
Kemi
monolayers
NATURAL SCIENCES
NATURVETENSKAP
Organic polymers
Physicochemistry of polymers
polyesters
Polymerization
polymers
Preparation, kinetics, thermodynamics, mechanism and catalysts
ring-opening polymerization
surfaces
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Summary:The use of Candida antarctica Lipase B (CALB) chemoselective catalyst in the Thiol End-Functionalization of Poly(ε-caprolacetone) was discussed. Thiol-functionalization of poly(ε-caprolacetone)(PCL) was made by an initiation reaction catalyzed by CALB in bulk. 2-Mercaptoethanol (1) was used to initiate the enzyme-assisted ring opening polymerization of ε-caprolacetone(2) to give the desired thiol-functionalized polymer. The structure of the terminated PCL was confirmed by 13 C nuclear magnetic resonance .
ISSN:0024-9297
1520-5835
1520-5835
DOI:10.1021/ma048056r