One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

An efficient one-pot one-step biocatalytic amine transaminase/acyl transferase cascade for the formation of amides from the corresponding aldehydes and ketones in aqueous solution has been developed. N -Benzyl-2-methoxyacetamide has been synthesized utilizing the developed cascade with conversions u...

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Bibliographic Details
Published in:Catalysis science & technology 2016-01, Vol.6 (9), p.2897-29
Main Authors: Land, Henrik, Hendil-Forssell, Peter, Martinelle, Mats, Berglund, Per
Format: Article
Language:English
Subjects:
Aldehydes
Amides
Amines
Cascades
Conversion
Formations
Ketones
Transaminases
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Summary:An efficient one-pot one-step biocatalytic amine transaminase/acyl transferase cascade for the formation of amides from the corresponding aldehydes and ketones in aqueous solution has been developed. N -Benzyl-2-methoxyacetamide has been synthesized utilizing the developed cascade with conversions up to 97%. The cascade was also evaluated for the synthesis of chiral amides. A novel biocatalytic amine transaminase/acyl transferase cascade for the formation of amides in aqueous solution has been developed.
ISSN:2044-4753
2044-4761
DOI:10.1039/c6cy00435k