Spatially well-defined carbohydrate nanoplatforms: synthesis, characterization and lectin interaction study

Two novel dodecasubstituted carbohydrate nanoplatforms based on molecular Borromean rings and dodecaamine cages have been prepared for use in evaluating the importance of the spatial distribution of carbohydrates in their interaction with lectins. The binding affinities of the glyconanoplatforms wer...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (83), p.12326-12329
Main Authors: Timmer, B J J, Flos, M Abellán, Jørgensen, L Mønster, Proverbio, D, Altun, S, Ramström, O, Aastrup, T, Vincent, S P
Format: Article
Language:English
Subjects:
Binding
Cages
Carbohydrate Conformation
Carbohydrates
Carbohydrates - chemistry
Concanavalin A - chemistry
Lectins
Lectins - chemistry
Microbalances
Models, Molecular
Nanostructure
Nanotechnology - methods
Quartz Crystal Microbalance Techniques
Quartz crystals
Spatial distribution
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Summary:Two novel dodecasubstituted carbohydrate nanoplatforms based on molecular Borromean rings and dodecaamine cages have been prepared for use in evaluating the importance of the spatial distribution of carbohydrates in their interaction with lectins. The binding affinities of the glyconanoplatforms were characterized using quartz crystal microbalance technology and compared with a monovalent reference and dodecaglycosylated fullerenes.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c6cc06737a