Synthesis of an Amino-Functionalized Model of the Fe-Only Hydrogenase Active Site

A dinuclear 2Fe2S mimic 6 of the active site of the Fe‐only hydrogenases has been synthesized. Complex 6 contains a free amino group which enables linkage to a protein backbone or to a redox active species for the study of electron transfer processes in proteins or in supramolecular systems. The str...

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Bibliographic Details
Published in:Chemistry : a European journal 2003-01, Vol.9 (2), p.557-560
Main Authors: Salyi, Szabolcs, Kritikos, Mikael, Åkermark, Björn, Sun, Licheng
Format: Article
Language:English
Subjects:
acid
Amines - chemistry
Binding Sites
bioinorganic chemistry
biomimetic synthesis
chemistry
coordination
desulfovibrio-desulfuricans
Hydrogenase - chemical synthesis
Hydrogenase - chemistry
Hydrogenase - metabolism
Iron - metabolism
iron carbonyl sulfides
iron hydrogenase
iron-only hydrogenase
mechanism
Models, Molecular
Molecular Mimicry
Molecular Structure
Oxidation-Reduction
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Summary:A dinuclear 2Fe2S mimic 6 of the active site of the Fe‐only hydrogenases has been synthesized. Complex 6 contains a free amino group which enables linkage to a protein backbone or to a redox active species for the study of electron transfer processes in proteins or in supramolecular systems. The structures of the complex 6 and its Boc‐protected precursor 5 could be verified by X‐ray crystallography. A functionalized biomimetic model of Fe‐only hydrogenases has been synthesized and verified by X‐ray crystallography. The complex (see scheme) contains a free amino group which allows linkage to a protein backbone or to a redoxactive species for the study of electron transfer processes in proteins or in supramolecular systems.
ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.200390058