Displacement of the equilibrium in lipase catalysed transesterification in ethyl octanoate by continous evaporation in ethanol

A simple method to overcome low equilibrium conversion in lipase catalysed resolution of alcohols by transesterification was developed. Ethyl octanoate was used as acyl donor as well as solvent and the reaction equilibrium was shifted by applying reduced pressure, forcing the co-product ethanol to e...

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Bibliographic Details
Published in:Biotechnology letters 1992-04, Vol.14 (4), p.263-268
Main Authors: Ohrner, N, Martinelle, M, Mattson, A, Norin, T, Hult, K
Format: Article
Language:English
Subjects:
2-octanol
alcohols
Biological and medical sciences
Biotechnology
Candida
Candida antarctica
catalytic activity
enantiomers
Enzyme engineering
equilibrium
esterification
ethanol
ethyl octanoate
evaporation
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Miscellaneous
pressure treatment
triacylglycerol lipase
yields
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Summary:A simple method to overcome low equilibrium conversion in lipase catalysed resolution of alcohols by transesterification was developed. Ethyl octanoate was used as acyl donor as well as solvent and the reaction equilibrium was shifted by applying reduced pressure, forcing the co-product ethanol to evaporate during the reaction. Using a lipase from Candida antarctica 2-octanol, 1-phenyl ethanol, 1-cyclohexyl ethanol and trans-2-methylcyclohexanol were resolved in good optical and chemical yields.
ISSN:0141-5492
1573-6776
1573-6776
DOI:10.1007/BF01022321