nucleotide sequence of Saccharomyces cerevisiae chromosome XV

Chromosome XV was one of the last two chromosomes of Saccharomyces cerevisiae to be discovered. It is the third-largest yeast chromosome after chromosomes XII and IV, and is very similar in size to chromosome VII. It alone represents 9% of the yeast genome (8% if ribosomal DNA is included). When sys...

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Bibliographic Details
Published in:Nature (London) 1997-05, Vol.387 (6632S), p.98-102
Main Authors: Dujon, B, Albermann, K, Aldea, M, Alexandraki, D, Ansorge, W, Arino, J, Benes, V, Bohn, C, Bolotin-Fukuhara, M, Bordonne, R
Format: Article
Language:English
Subjects:
Base Sequence
Bioengineering
Bioteknik
Chromosomes
Chromosomes, Fungal
Deoxyribonucleic acid
DNA
DNA, Fungal
Genes
Life sciences
Microbiologie
Microbiology
nucleotide sequences
Open Reading Frames
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Sciences du vivant
TECHNOLOGY
TEKNIKVETENSKAP
Yeast
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Summary:Chromosome XV was one of the last two chromosomes of Saccharomyces cerevisiae to be discovered. It is the third-largest yeast chromosome after chromosomes XII and IV, and is very similar in size to chromosome VII. It alone represents 9% of the yeast genome (8% if ribosomal DNA is included). When systematic sequencing of chromosome XV was started, 93 genes or markers were identified, and most of them were mapped. However, very little else was known about chromosome XV which, in contrast to shorter chromosomes, had not been the object of comprehensive genetic or molecular analysis. It was therefore decided to start sequencing chromosome XV only in the third phase of the European Yeast Genome Sequencing Programme, after experience was gained on chromosomes III, XI and II (refs 3-5). The sequence of chromosome XV has been determined from a set of partly overlapping cosmic clones derived from a unique yeast strain, and physically mapped at 3.3-kilobase resolution before sequencing. As well as numerous new open reading frames (ORFs) and genes encoding tRNA or small RNA molecules, the sequence of 1,091, 283 base pairs confirms the high proportion of orphan genes and reveals a number of ancestral and successive duplications with other yeast chromosomes.
ISSN:0028-0836
1476-4687
1476-4687
DOI:10.1038/387s098