Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc

Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extract...

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Bibliographic Details
Published in:International journal of biological macromolecules 2019-08, Vol.135, p.29-37
Main Authors: Li, Jing, Wang, Damao, Xing, Xiaohui, Cheng, Ting-Jen Rachel, Liang, Pi-Hui, Bulone, Vincent, Park, Jeong Hill, Hsieh, Yves S.Y.
Format: Article
Language:English
Subjects:
Animals
Cell Wall - chemistry
Cell wall polysaccharides
Fiber- och polymervetenskap
Fibre and Polymer Science
Ginseng marc
Hydrolysis
Immunologic Factors - chemistry
Immunologic Factors - isolation & purification
Immunologic Factors - pharmacology
Liquid-Liquid Extraction
Mice
Murine macrophage cells
Panax - chemistry
Panax ginseng
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
RAW 264.7 Cells
Spectrum Analysis
Structure
Structure-Activity Relationship
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Summary:Ginseng marc is a major by-product of the ginseng industry currently used as animal feed or fertilizer. This fibrous, insoluble waste stream is rich in cell wall polysaccharides and therefore a potential source of ingredients for functional food with health-promoting properties. However, the extraction of these polysaccharides has proved problematic and their exact composition remains unknown. Here we have analysed the composition, structure and biological activity of polysaccharides from ginseng root, stem and leaf marc fractionated using a chelator and alkali solutions. The pectic fraction has been extracted from root marc in high abundance and can activate the production of interleukine-1α and the hematopoietic growth factor by RAW 264.7 murine macrophage cells, which are important immune regulators of T-cells during inflammatory responses and infection processes. Our study reveals the potential to increase the value of ginseng marc by generating carbohydrate-based products with a higher value than animal feed. [Display omitted]
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2019.05.077