Human monoclonal Fab and human plasma antibodies to carbamyl‐epitopes cross‐react with malondialdehyde‐adducts

Summary Oxidized low‐density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associa...

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Bibliographic Details
Published in:Immunology 2014-03, Vol.141 (3), p.416-430
Main Authors: Kummu, Outi, Turunen, S. Pauliina, Prus, Piotr, Lehtimäki, Jaakko, Veneskoski, Marja, Wang, Chunguang, Hörkkö, Sohvi
Format: Article
Language:English
Subjects:
Acetaldehyde - blood
Acetaldehyde - immunology
Animals
Antibodies, Monoclonal - blood
Antibodies, Monoclonal - immunology
antibody
Apoptosis
atherosclerosis
Atherosclerosis - blood
Atherosclerosis - immunology
Autoantibodies - blood
Autoantibodies - immunology
Binding, Competitive
carbamylation
Cell Surface Display Techniques
Cholesterol
Cross Reactions
cross-reaction
Disease Models, Animal
Epitopes
Humans
Immunity, Humoral
Immunoglobulin Fab Fragments - blood
Immunoglobulin Fab Fragments - immunology
Jurkat Cells
Lipoproteins, LDL - blood
Lipoproteins, LDL - immunology
Low density lipoprotein
Macrophages - immunology
Macrophages - metabolism
Malondialdehyde - analogs & derivatives
Malondialdehyde - blood
Malondialdehyde - immunology
Mice
Original
Oxidation-Reduction
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
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Summary:Summary Oxidized low‐density lipoprotein (OxLDL) plays a crucial role in the development of atherosclerosis. Carbamylated LDL has been suggested to promote atherogenesis in patients with chronic kidney disease. Here we observed that plasma IgG and IgM antibodies to carbamylated epitopes were associated with IgG and IgM antibodies to oxidation‐specific epitopes (ρ = 0·65–0·86, P 
ISSN:0019-2805
1365-2567
1365-2567
DOI:10.1111/imm.12204