Software sensors for fermentation processes

Four software sensors based on standard on-line data from fermentation processes and simple mathematical models were used to monitor a number of state variables in Escherichia coli fed-batch processes: the biomass concentration, the specific growth rate, the oxygen transfer capacity of the bioreacto...

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Bibliographic Details
Published in:Bioprocess and biosystems engineering 2008-02, Vol.31 (2), p.145-152
Main Authors: Sundström, Heléne, Enfors, Sven-Olof
Format: Article
Language:English
Subjects:
Algorithms
Biochemical process engineering
Bioengineering
Biokemisk och bioteknisk processteknik
Biological and medical sciences
Biomass
Bioreactors
Bioreactors - microbiology
Biosensors
Biotechnology
Bioteknik
Cell Proliferation
Chemistry
Chemistry and Materials Science
Computer Simulation
E coli
Environmental Engineering/Biotechnology
Escherichia coli
Escherichia coli - physiology
Escherichia coli Proteins - metabolism
Fermentation
Food Science
Fundamental and applied biological sciences. Psychology
Industrial and Production Engineering
Industrial Chemistry/Chemical Engineering
Mathematical models
Models, Biological
Original Paper
Oxygen - metabolism
Oxygen transfer
Sensors
Software
TECHNOLOGY
TEKNIKVETENSKAP
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Summary:Four software sensors based on standard on-line data from fermentation processes and simple mathematical models were used to monitor a number of state variables in Escherichia coli fed-batch processes: the biomass concentration, the specific growth rate, the oxygen transfer capacity of the bioreactor, and the new R O/S sensor which is the ratio between oxygen and energy substrate consumption. The R O/S variable grows continuously in a fed-batch culture with constant glucose feed, which reflects the increasing maintenance demand at declining specific growth rate. The R O/S sensor also responded to rapid pH shift-downs reflecting the increasing demand for maintenance energy. It is suggested that this sensor may be used to monitor the extent of physiological stress that demands energy for survival.
ISSN:1615-7591
1615-7605
1615-7605
DOI:10.1007/s00449-007-0157-5