Surface functionalization of degradable polymers by covalent grafting

With a new non-destructive and solvent-free photografting technique, N-vinylpyrrolidone was covalently grafted onto the surfaces of degradable polymers; poly( l-lactide), poly( ε-caprolactone), poly(lactide- co-glycolide), and poly(trimethylene carbonate). The modified surfaces were characterized by...

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Bibliographic Details
Published in:Biomaterials 2006-03, Vol.27 (9), p.1788-1796
Main Authors: Källrot, Martina, Edlund, Ulrica, Albertsson, A.-C.
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biocompatible Materials - radiation effects
Biodegradation, Environmental
Cell Adhesion
Cell Proliferation
Cells, Cultured
Chemistry
Covalent
Degradable
Dioxanes - chemistry
Dioxanes - pharmacology
Dioxanes - radiation effects
Fibroblasts - drug effects
Humans
Kemi
N-vinyl pyrrolidone
NATURAL SCIENCES
NATURVETENSKAP
Organic chemistry
Organisk kemi
Photochemistry
Polyesters - chemistry
Polyesters - pharmacology
Polyesters - radiation effects
Polyglactin 910 - chemistry
Polyglactin 910 - pharmacology
Polyglactin 910 - radiation effects
Polymer chemistry
Polymerkemi
Polymers - chemistry
Polymers - pharmacology
Polymers - radiation effects
Pyrrolidinones - chemistry
Pyrrolidinones - pharmacology
Pyrrolidinones - radiation effects
Skin - cytology
Solvent free
Surface modification
Surface Properties - drug effects
Surface Properties - radiation effects
Ultraviolet Rays
Vapor-phase grafting
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Description
Summary:With a new non-destructive and solvent-free photografting technique, N-vinylpyrrolidone was covalently grafted onto the surfaces of degradable polymers; poly( l-lactide), poly( ε-caprolactone), poly(lactide- co-glycolide), and poly(trimethylene carbonate). The modified surfaces were characterized by XPS, ATR-FTIR, SEM, and cell growth tests. The wettability was markedly improved, as static contact angles changed from about 80° for the pristine substrates to around 30° after 30 min of grafting. Well-defined surface topographies, such as micro-patterns, are preserved in the process since the graft layers are thin. The biological response, measured as cytotoxicity, showed that the modified films provide good substrates, comparable with optimized cell culture plastics, for the adhesion and proliferation of normal human keratinocytes and skin fibroblasts.
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2005.10.010