Photodynamic effects of zinc oxide nanowires in skin cancer and fibroblast

Cytotoxic effects of zinc oxide (ZnO) nanomaterials, individual and conjugated with a photosensitizer (protoporphyrin IX), were studied in the presence and absence of ultraviolet light exposure (240 nm of light wavelength for a very short time exposure) in cell cultures of human normal and cancerous...

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Bibliographic Details
Published in:Lasers in medical science 2014-05, Vol.29 (3), p.1189-1194
Main Authors: Fakhar-e-Alam, Muhammad, Kishwar, S., Willander, M.
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cell Survival - drug effects
Cell Survival - radiation effects
Dentistry
Drug Delivery Systems
Fibroblasts - drug effects
Fibroblasts - radiation effects
Humans
Lasers
Male
Medicine
Medicine & Public Health
Melanoma - drug therapy
Nanowires
Nanowires - therapeutic use
Nanowires - ultrastructure
Optical Devices
Optics
Original Article
Photochemotherapy
Photodynamic therapy
Photonics
Photosensitizing Agents - therapeutic use
Protoporphyrins - therapeutic use
Quantum Optics
Skin cancer
Skin Neoplasms - drug therapy
TECHNOLOGY
TEKNIKVETENSKAP
Ultraviolet Rays
Zinc Oxide - therapeutic use
Zinc oxides
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Summary:Cytotoxic effects of zinc oxide (ZnO) nanomaterials, individual and conjugated with a photosensitizer (protoporphyrin IX), were studied in the presence and absence of ultraviolet light exposure (240 nm of light wavelength for a very short time exposure) in cell cultures of human normal and cancerous skin models. Zinc Oxide nanowires (ZnO NWs) were grown on the capillary tip and conjugated with protoporphyrin IX (PpIX). This coated tip was used as tool/pointer for intracellular drug delivery protocol in suggested normal as well as carcinogenic cellular models. After true delivery of optimal drug, the labelled biological model was irradiated with UV-A, which led to a loss of mitochondrial membrane potential, as tested by neutral red assay (NRA).
ISSN:0268-8921
1435-604X
1435-604X
DOI:10.1007/s10103-013-1501-4