CD93 gene polymorphism is associated with disseminated colorectal cancer

Purpose Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer. We evaluated the expression of CD93 and the association with two single nucleotide polymorphi...

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Bibliographic Details
Published in:International journal of colorectal disease 2015-07, Vol.30 (7), p.883-890
Main Authors: Olsen, Renate S., Lindh, Mikael, Vorkapic, Emina, Andersson, Roland E., Zar, Niklas, Löfgren, Sture, Dimberg, Jan, Matussek, Andreas, Wågsäter, Dick
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Apoptosis
Blotting, Western
Cancer
Case-Control Studies
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Development and progression
Diagnosis
Disease-Free Survival
Enzyme-Linked Immunosorbent Assay
Enzymes
Female
Gastroenterology
Gene expression
Gene Frequency - genetics
Genes
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease
Genetic research
Hepatology
Humans
Immunohistochemistry
Inflammation
Internal Medicine
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Membrane Glycoproteins - blood
Membrane Glycoproteins - genetics
Middle Aged
Neoplasm Staging
Original
Original Article
Polymorphism, Single Nucleotide - genetics
Proctology
Receptors, Complement - blood
Receptors, Complement - genetics
Single nucleotide polymorphisms
Solubility
Surgery
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Summary:Purpose Cluster of differentiation 93 (CD93) is involved in apoptosis and inflammation and has a suggested role in angiogenesis, and all of which are involved in the development and dissemination of cancer. We evaluated the expression of CD93 and the association with two single nucleotide polymorphisms (SNPs), rs2749812 and rs2749817, as possible biomarkers in colorectal cancer (CRC). Methods Tissue levels and plasma levels of CD93 were measured using an enzyme-linked immunosorbent assay (ELISA). Expression of CD93 was determined by immunohistochemistry, western blot and gene expression analysis. Genotype frequencies were established for the SNPs by real-time polymerase chain reaction (PCR), and the association with tumour stage and survival was analysed. Results Total CD93 levels were 82 % higher ( P  
ISSN:0179-1958
1432-1262
1432-1262
DOI:10.1007/s00384-015-2247-1