A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery

The aim of this study was to adapt and evaluate laser Doppler perfusion monitoring (LDPM) together with custom-designed brain probes and software for continuous recording of cerebral microcirculation in patients undergoing neurosurgery. The LDPM system was used to record perfusion and backscattered...

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Bibliographic Details
Published in:Medical & biological engineering & computing 2016, Vol.54 (1), p.123-131
Main Authors: Rejmstad, Peter, Åkesson, Gustav, Åneman, Oscar, Wårdell, Karin
Format: Article
Language:English
Subjects:
Adjustable
Adult
Aged
Analysis
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Brain
Brain cancer
Brain tumour Laser Doppler perfusion monitoring (LDPM)
Cerebrovascular Circulation
Circulatory system
Computer Applications
Computer programs
Design
Female
Heart rate
Hemorrhage
Human Physiology
Humans
Imaging
Laser-Doppler Flowmetry - instrumentation
Lasers
Male
Medical imaging
Microcirculation
Middle Aged
Monitoring
Neurosurgery
Neurosurgical Procedures
Original Article
Patients
Postoperative period
Pulsatility index (PI)
Radiology
Signal processing
Software
Studies
Surgery
Systems stability
Traumatic brain injury
Tumors
Tumours
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Summary:The aim of this study was to adapt and evaluate laser Doppler perfusion monitoring (LDPM) together with custom-designed brain probes and software for continuous recording of cerebral microcirculation in patients undergoing neurosurgery. The LDPM system was used to record perfusion and backscattered light (TLI). These parameters were displayed together with the extracted heart rate (HR), pulsatility index (PI) and signal trends from adjustable time intervals. Technical evaluation was done on skin during thermal provocation. Clinical measurements were performed on ten patients undergoing brain tumour surgery. Data from 76 tissue sites were captured with a length varying between 10 s to 15 min. Statistical comparisons were done using Mann–Whitney tests. Grey and tumour tissue could be separated from white matter using the TLI signal ( p  
ISSN:0140-0118
1741-0444
1741-0444
DOI:10.1007/s11517-015-1332-5