Long-term outcomes of destructive seronegative (rheumatoid) arthritis - description of four clinical cases

Seronegative rheumatoid arthritis is associated with a milder course of progression compared to seropositive disease. However, long-term follow-up data of the clinical course of seronegative rheumatoid arthritis are sparse. Here we describe four cases with a rare disease entity of aggressive destruc...

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Published in:BMC musculoskeletal disorders 2016-06, Vol.17 (1), p.246-246, Article 246
Main Authors: Nikiphorou, Elena, Sjöwall, Christopher, Hannonen, Pekka, Rannio, Tuomas, Sokka, Tuulikki
Format: Article
Language:English
Subjects:
Adult
Aged
Ankle
Antibodies
Arthritis
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - therapy
Care and treatment
Case Report
Clinical outcomes
Demographics
Development and progression
Disease Progression
Female
Humans
Joint surgery
Knee
Middle Aged
Musculoskeletal diseases
Patient outcomes
Patients
Radiography
Rheumatoid arthritis
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creator Nikiphorou, Elena
Sjöwall, Christopher
Hannonen, Pekka
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description Seronegative rheumatoid arthritis is associated with a milder course of progression compared to seropositive disease. However, long-term follow-up data of the clinical course of seronegative rheumatoid arthritis are sparse. Here we describe four cases with a rare disease entity of aggressive destructive seronegative (rheumatoid) arthritis with 20-35 years of follow-up. The four cases are women with an initial presentation of seronegative rheumatoid arthritis in 1980-1996 and have received disease-modifying anti-rheumatic drugs since the diagnosis. In all cases, the condition has been refractory to treatments and evolved into a severe disease with destructions of the wrists, sub-talar and ankle joints, as well as large joints but not small joints of fingers and toes. All cases are negative with regard to rheumatoid factor, anti-cyclic citrullinated peptide antibodies and antibodies against carbamylated proteins. This report adds to the existing literature, making the reader aware of this sub-type of inflammatory arthritis which despite being seronegative, can have devastating disease consequences. The report highlights the need for further research into this field in order to better understand this disease sub-type, the pathogenesis, disease course and outcomes.
doi_str_mv 10.1186/s12891-016-1067-y
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ispartof BMC musculoskeletal disorders, 2016-06, Vol.17 (1), p.246-246, Article 246
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subjects Adult
Aged
Ankle
Antibodies
Arthritis
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - therapy
Care and treatment
Case Report
Clinical outcomes
Demographics
Development and progression
Disease Progression
Female
Humans
Joint surgery
Knee
Middle Aged
Musculoskeletal diseases
Patient outcomes
Patients
Radiography
Rheumatoid arthritis
title Long-term outcomes of destructive seronegative (rheumatoid) arthritis - description of four clinical cases
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