Targeting cancer cells with controlled release nanocapsules based on a single aptamer

Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the firs...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (13), p.1285
Main Authors: Hernandez, Frank J, Hernandez, Luiza I, Pinto, Alessandro, Schäfer, Thomas, Özalp, Veli C
Format: Article
Language:English
Subjects:
Aptamers, Nucleotide - chemistry
Aptamers, Nucleotide - genetics
Aptamers, Nucleotide - metabolism
Cell Line, Tumor
Delayed-Action Preparations
Fluorescein - chemistry
Humans
Inverted Repeat Sequences
Models, Molecular
Nanocapsules - chemistry
Nucleic Acid Conformation
Nucleolin
Phosphoproteins - metabolism
Porosity
RNA-Binding Proteins - metabolism
Silicon Dioxide - chemistry
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Summary:Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c2cc37370j