AMPA-selective glutamate receptor subunits and their relation to glutamate-and GABA-like immunoreactive terminals in the nucleus submedius of the rat

Glutamate plays an important role in supraspinal nociceptive systems. Thus, glutamate is present in the nucleus submedius of the medial thalamus, a major relay for nociceptive information. In this study, immunoreactivity for the four subunits (GluR1–4) of α-amino-3-hydroxy-5-methyl-4-isoxasolepropri...

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Bibliographic Details
Published in:Neuroscience letters 1996-10, Vol.217 (2), p.149-152
Main Authors: Hamlin, Lina, Mackerlova, Ludmila, Blomqvist, Anders, Ericson, Ann-Charlott
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Electron microscopy
Fundamental and applied biological sciences. Psychology
gamma-Aminobutyric Acid - metabolism
gamma-Aminobutyric Acid - physiology
Glutamate
Glutamic Acid - metabolism
Glutamic Acid - physiology
Immunohistochemistry
Male
Microscopy, Electron
Non- N-methyl- d-aspartate
Pain
Postembedding immunohistochemistry
Presynaptic Terminals - metabolism
Presynaptic Terminals - physiology
Presynaptic Terminals - ultrastructure
Rats
Rats, Sprague-Dawley
Receptor
Receptors, AMPA - physiology
Synaptic Transmission - physiology
Thalamic Nuclei - cytology
Thalamic Nuclei - physiology
Thalamic Nuclei - ultrastructure
Thalamus
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
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Summary:Glutamate plays an important role in supraspinal nociceptive systems. Thus, glutamate is present in the nucleus submedius of the medial thalamus, a major relay for nociceptive information. In this study, immunoreactivity for the four subunits (GluR1–4) of α-amino-3-hydroxy-5-methyl-4-isoxasoleproprionate (AMPA) receptors was examined by a preembedding immunohistochemical method in order to evaluate the presence of this glutamate receptor subtype in the nucleus submedius. Combining the preembedding method with a postembedding immunogold technique, we found that AMPA receptor-like immunoreactivity was present postsynaptically to glutamatergic terminals but not to terminals containing γ-arninobutyric acid (GABA). These findings suggest a role for AMPA receptors in excitatory synaptic transmission in the nucleus submedius of the rat thalamus.
ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/0304-3940(96)13093-7