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High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer
To investigate the association and prognostic value of gene for survival in colorectal cancer, the mechanism of level alteration and correlated signaling pathways is involved. The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. High expression is associated with poo...
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| Published in: | Future oncology (London, England) England), 2019-06, Vol.15 (18), p.2093-2106 |
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| Main Authors: | , , , , |
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| cites | cdi_FETCH-LOGICAL-c359t-72c02946469f9411111ba27ee4b6e37552a5baddb8d4e3d592f30103a89e6be43 |
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| container_issue | 18 |
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| container_title | Future oncology (London, England) |
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| creator | Zhou, Xin Shang, Yan-Na Lu, Ran Fan, Chuan-Wen Mo, Xian-Ming |
| description | To investigate the association and prognostic value of
gene for survival in colorectal cancer, the mechanism of
level alteration and correlated signaling pathways
is involved.
The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation.
High
expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p = 0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p = 0.042) in colon cancer. Bioinformatical analysis showed
was upregulated by amplification and exon expression.
was associated with angiogenesis and cancer signaling pathways.
High
is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways. |
| doi_str_mv | 10.2217/fon-2018-0920 |
| format | article |
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gene for survival in colorectal cancer, the mechanism of
level alteration and correlated signaling pathways
is involved.
The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation.
High
expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p = 0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p = 0.042) in colon cancer. Bioinformatical analysis showed
was upregulated by amplification and exon expression.
was associated with angiogenesis and cancer signaling pathways.
High
is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.</description><identifier>ISSN: 1479-6694</identifier><identifier>ISSN: 1744-8301</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2018-0920</identifier><identifier>PMID: 31257922</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Biomarkers ; Biomarkers, Tumor ; Cancer therapies ; Carrier Proteins - genetics ; Cell cycle ; Chemotherapy ; Colonic Neoplasms - genetics ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colonic Neoplasms - therapy ; Colorectal cancer ; Computational Biology - methods ; Female ; Gene Expression ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Inflammatory bowel disease ; Kaplan-Meier Estimate ; Kinases ; Male ; Medical prognosis ; Metastasis ; Microsatellite Instability ; Middle Aged ; Mutation ; Neoplasm Grading ; Neoplasm Staging ; Patients ; Prognosis ; Proteins ; Quality control ; Surveillance ; Survival Analysis</subject><ispartof>Future oncology (London, England), 2019-06, Vol.15 (18), p.2093-2106</ispartof><rights>Copyright Future Medicine Ltd Jun 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-72c02946469f9411111ba27ee4b6e37552a5baddb8d4e3d592f30103a89e6be43</citedby><cites>FETCH-LOGICAL-c359t-72c02946469f9411111ba27ee4b6e37552a5baddb8d4e3d592f30103a89e6be43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31257922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160630$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Shang, Yan-Na</creatorcontrib><creatorcontrib>Lu, Ran</creatorcontrib><creatorcontrib>Fan, Chuan-Wen</creatorcontrib><creatorcontrib>Mo, Xian-Ming</creatorcontrib><title>High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>To investigate the association and prognostic value of
gene for survival in colorectal cancer, the mechanism of
level alteration and correlated signaling pathways
is involved.
The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation.
High
expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p = 0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p = 0.042) in colon cancer. Bioinformatical analysis showed
was upregulated by amplification and exon expression.
was associated with angiogenesis and cancer signaling pathways.
High
is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor</subject><subject>Cancer therapies</subject><subject>Carrier Proteins - genetics</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - therapy</subject><subject>Colorectal cancer</subject><subject>Computational Biology - methods</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Genomics</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Kaplan-Meier Estimate</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Quality control</subject><subject>Surveillance</subject><subject>Survival Analysis</subject><issn>1479-6694</issn><issn>1744-8301</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkU1PFTEUhhuDAUSXbkkTNm6q_e7t8gZFjEQ34MJN0-mcgZLe6dDeuei_txO-Ers5Tc6TN-_Jg9B7Rj9yzsynIY-EU7Yi1HL6Ch0yIyVZCcr22l8aS7S28gC9qfWWUmmEovvoQDCujOX8EKXzeH2D1z--_z5jGP5MBWqNecSxYl9rDtFvocf3cXuDp5wLzjsoPiVc57KLO5-wH3tcIMylwBiADAXgZRlHHHJqccG3ZXmLXg8-VXj3OI_Q1dmXy9NzcvHz67fT9QUJQtktMTxQbqWW2g5WsuV1nhsA2WkQRinuVef7vlv1EkSvLB_avVT4lQXdgRRHiDzk1nuY5s5NJW58-euyj-5z_LV2uVy7FGfHNNWCNv7DAz-VfDdD3bpNrAFS8iPkuTrOFdVcULVEn_yH3ua5jO2aRhnBeeurXgqEkmstMDxXYNQt2lzT5hZtbtHW-OPH1LnbQP9MP3kS_wCThZLY</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Zhou, Xin</creator><creator>Shang, Yan-Na</creator><creator>Lu, Ran</creator><creator>Fan, Chuan-Wen</creator><creator>Mo, Xian-Ming</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope></search><sort><creationdate>20190601</creationdate><title>High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer</title><author>Zhou, Xin ; Shang, Yan-Na ; Lu, Ran ; Fan, Chuan-Wen ; Mo, Xian-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-72c02946469f9411111ba27ee4b6e37552a5baddb8d4e3d592f30103a89e6be43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor</topic><topic>Cancer therapies</topic><topic>Carrier Proteins - genetics</topic><topic>Cell cycle</topic><topic>Chemotherapy</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - mortality</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - therapy</topic><topic>Colorectal cancer</topic><topic>Computational Biology - methods</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Genomics</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Kaplan-Meier Estimate</topic><topic>Kinases</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Quality control</topic><topic>Surveillance</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Shang, Yan-Na</creatorcontrib><creatorcontrib>Lu, Ran</creatorcontrib><creatorcontrib>Fan, Chuan-Wen</creatorcontrib><creatorcontrib>Mo, Xian-Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xin</au><au>Shang, Yan-Na</au><au>Lu, Ran</au><au>Fan, Chuan-Wen</au><au>Mo, Xian-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>15</volume><issue>18</issue><spage>2093</spage><epage>2106</epage><pages>2093-2106</pages><issn>1479-6694</issn><issn>1744-8301</issn><eissn>1744-8301</eissn><abstract>To investigate the association and prognostic value of
gene for survival in colorectal cancer, the mechanism of
level alteration and correlated signaling pathways
is involved.
The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation.
High
expression is associated with poor overall survival (hazard ratio [HR]: 2.094; 95% CI: 1.188-3.689; p = 0.011) and recurrence-free survival (HR: 1.762; 95% CI: 1.021-3.042; p = 0.042) in colon cancer. Bioinformatical analysis showed
was upregulated by amplification and exon expression.
was associated with angiogenesis and cancer signaling pathways.
High
is an independent factor of poor survival (overall survival and recurrence-free survival) in colon cancer by taking part in angiogenesis and some cancer signaling pathways.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31257922</pmid><doi>10.2217/fon-2018-0920</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 1479-6694 |
| ispartof | Future oncology (London, England), 2019-06, Vol.15 (18), p.2093-2106 |
| issn | 1479-6694 1744-8301 1744-8301 |
| language | eng |
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| source | PubMed (Medline) |
| subjects | Adult Aged Aged, 80 and over Apoptosis Biomarkers Biomarkers, Tumor Cancer therapies Carrier Proteins - genetics Cell cycle Chemotherapy Colonic Neoplasms - genetics Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - therapy Colorectal cancer Computational Biology - methods Female Gene Expression Genomics High-Throughput Nucleotide Sequencing Humans Inflammatory bowel disease Kaplan-Meier Estimate Kinases Male Medical prognosis Metastasis Microsatellite Instability Middle Aged Mutation Neoplasm Grading Neoplasm Staging Patients Prognosis Proteins Quality control Surveillance Survival Analysis |
| title | High ANKZF1 expression is associated with poor overall survival and recurrence-free survival in colon cancer |
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