The Influence of Adjuvant Radiotherapy and Single Nucleotide Polymorphisms on Circulating Immune Response Cell Numbers and Phenotypes of Patients With Breast Cancer

Adjuvant radiotherapy (RT) damages multiple layers of skin, muscle, blood vessels and blood cells that are included within the RT area. Indirect, bystander systemic effects could also develop in cells not directly hit by radiation. Ninety-three female patients recovering from breast cancer surgery a...

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Bibliographic Details
Published in:Anticancer research 2019-09, Vol.39 (9), p.4957-4963
Main Authors: Lewin, Nongnit Laytragoon, Luetragoon, Thitiya, Shamoun, Levar, Oliva, Delmy, Andersson, Bengt-Åke, Löfgren, Sture, Rutqvist, Lars Erik, Lewin, Freddi
Format: Article
Language:English
Subjects:
Adaptive immunity
Biomarkers
Blood & organ donations
Blood cells
Blood donors
Blood vessels
Breast cancer
Immune response
Immune system
Immunotherapy
Innate immunity
Lymphocytes T
Mastectomy
Muscles
Nucleotides
Patients
Phenotypes
Platelets
Radiation
Radiation therapy
Single-nucleotide polymorphism
Skin
Subpopulations
Surgery
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Summary:Adjuvant radiotherapy (RT) damages multiple layers of skin, muscle, blood vessels and blood cells that are included within the RT area. Indirect, bystander systemic effects could also develop in cells not directly hit by radiation. Ninety-three female patients recovering from breast cancer surgery and 82 female healthy blood donors were analyzed. For identification of systemic adaptive and innate immune response, rapid and low-cost blood-based biomarkers were assayed. Post-operated breast cancer patients had a decreased number of circulating adaptive immune response cells but increased number of circulating immunosuppressive myeloid subpopulations. RT decreased the number of T-cells and platelets without influencing the number of immunosuppressive myeloid subpopulations. Alterations in the number and phenotypes of T-cell subpopulations were associated with SNPs. The combination of RT and immunotherapy might provide optimal treatment for cancer patients.
ISSN:0250-7005
1791-7530
1791-7530
DOI:10.21873/anticanres.13684